CUVPOSA (glycopyrrolate) an FDA-approved treatment indicated to reduce Chronic Severe Drooling in patients aged 3-16 years with neurologic conditions associated with problem drooling (eg, cerebral palsy).1

Liquid formulation: designed with purpose

Liquid formulation icon

Convenient for your patient

Helps ensure that your patient receives the intended dose.*

*Use an accurate dose-measuring cup to get the right dose of CUVPOSA.1

Convenient cup icon

Convenient for your caregiver

No mixing or pill crushing.† No more asking your patient to finish their food so they receive the proper dose.

†Give CUVPOSA at least 1 hour before or 2 hours after meals.1

Oral syringe icon

Convenient for you

Easy to titrate based on your patient's needs to deliver an individualized dose.

Study design1

CUVPOSA was evaluated in a multi-center, randomized, double-blind, placebo-controlled, parallel, eight-week study for the control of pathologic drooling in children (Study 1). The study enrolled 38 subjects aged 3-23 years; thirty-six subjects were aged 3-16 years and two patients were greater than 16 years.

The subjects were male or female, weighed at least 13 kg (27 lbs), and had cerebral palsy, mental retardation, or another neurologic condition associated with problem drooling defined as drooling in the absence of treatment so that clothing became damp on most days (approximately five to seven days per week).

Subjects were randomized in a 1:1 fashion to receive CUVPOSA or placebo. Doses of study medication were titrated over a 4-week period to optimal response beginning at 0.02 mg/kg three times a day increasing doses in increments of approximately 0.02 mg/kg three times per day every 5-7 days, not to exceed the lesser of approximately 0.1 mg/kg three times per day or 3 mg three times per day.